By Mari Hoffman, Genetics and Genomics ‘21 Author’s Note: I chose to interview Dr.LaSalle because of my interest in epigenetics and the relationship that our genes have with environmental interactions. Dr. LaSalle’s lab focuses on the role of epigenetics in the human autism-spectrum and many other neurodegenerative disorders. Her research group looks at the pathogenesis of the disorders by focusing on heritable changes that are not encoded in the DNA, such as DNA methylation and imprinted genes. It was an honor to get to talk to Dr. LaSalle about her research, as she is extremely passionate about this very complex and exciting topic.
By Ashley Chang, Genetics ’15 Biostatisticians led by Knut Wittkowski at Rockefeller University Hospital have employed new methods of genome-wide association studies to identify genes that they believe to be associated with autism. The researchers compared genomes of patients with varying degrees of autism to healthy patients and were able to identify genetic variations that seem to be linked to the pathology of neural development in young children. The technique used to identify these genes is unique. Rather than traditional genome association, which searches for single nucleotide polymorphisms (SNPs), this new method looks for combinations of several SNPs that are common in patients with a disease. Wittkowski also compared this new autism profile to patients with childhood epilepsy and found […]