Human umbilical cord mesenchymal stem cells (hUC-MSC) have been a recent area of interest within regenerative medicine. In association with hUC-MSC, the phosphoinositide 3-kinase/protein kinase B/mammalian target of the rapamycin pathway (PI3K/AKT/mTOR) is a secretory pathway responsible for regulating a variety of cell functions. The processes between the hUC-MSCs and the PI3K/AKT/mTOR are commonly interdependent, but due to their novelty, most of the mechanisms in this relationship are still unknown. This review will discuss the potential of using hUC-MSCs in conjunction with the PI3K/AKT/mTOR for future regenerative treatment.

One important aspect of stem cells is their high activity of the Wnt signaling pathway. In the animal Hydra vulgaris this pathway is active in some capacity at all times and is very active during regeneration. It is also active during the growth of ectopic heads, which are heads that grow on the wrong part of the Hydra or in addition to an already established head. Hydra is a model organism for studying countless molecular processes due to its structural simplicity and incredible regenerative abilities making it an ideal tool for studying the Wnt signaling pathway. This review will describe new research on the activity of β-catenin, GSK-3β, and general Wnt signaling during regeneration and ectopic head formation and prevention in Hydra.