Global crop yields are at their highest in recorded history, but to prioritize higher yields farmers are incentivized to use chemical fertilizers and pesticides. These can disrupt the crop’s ability to extract micronutrients such as vitamins, minerals, and amino acids from the soil, which ultimately produces a less nutritional crop. A solution developed in recent years has been regenerative farming - a collection of sustainable practices whose primary focus is revitalizing farm soil while maintaining yield. This review will explore the long-term decline in iron, zinc, and copper concentrations for many crops, its implications for the human immune system, and how regenerative farming can alleviate these trends.

Defects in neurulation, a process in vertebrate embryonic development that forms the neural tube and eventually the central nervous system, lead to a range of disorders characterized by malformation of the brain and spinal cord. Past studies have shown that folate, a nutrient involved in the biomolecule-synthesizing one-carbon metabolism, plays a vital role in reducing the occurrence of these congenital malformations. Further investigation of lesser-known nutrients involved in the one-carbon metabolism may provide new insight on preventative measures. In this review, we highlight the current understanding of nutrients implicated in the embryonic process of neurulation and how they are interrelated in one-carbon metabolism.

Integrating dietary treatments with chemotherapy and immunotherapy has emerged as a viable technique to improve cancer treatment success in recent years. One such example are ketogenic diets, which have garnered attention for their anti-tumor and anti-inflammatory characteristics among various dietary treatments. This review examines the effect of a ketogenic diet in combination with chemotherapy or immunotherapy on cancer patient survival rates.