Defects in neurulation, a process in vertebrate embryonic development that forms the neural tube and eventually the central nervous system, lead to a range of disorders characterized by malformation of the brain and spinal cord. Past studies have shown that folate, a nutrient involved in the biomolecule-synthesizing one-carbon metabolism, plays a vital role in reducing the occurrence of these congenital malformations. Further investigation of lesser-known nutrients involved in the one-carbon metabolism may provide new insight on preventative measures. In this review, we highlight the current understanding of nutrients implicated in the embryonic process of neurulation and how they are interrelated in one-carbon metabolism.
Integrating dietary treatments with chemotherapy and immunotherapy has emerged as a viable technique to improve cancer treatment success in recent years. One such example are ketogenic diets, which have garnered attention for their anti-tumor and anti-inflammatory characteristics among various dietary treatments. This review examines the effect of a ketogenic diet in combination with chemotherapy or immunotherapy on cancer patient survival rates.