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Insulin Resistance in Polycystic Ovary Syndrome and its Impact on Women’s Fertility

Introduction 

Polycystic Ovary Syndrome (PCOS) is a chronic hormonal and metabolic disorder that affects 15% of reproductive-aged women globally [1]. In the recent decade, there has been on average a 10% increase in the proportion of women around the world diagnosed with polycystic ovary syndrome [2]. Women with PCOS experience a cascade of sexual hormone imbalances, menstrual abnormalities, and fertility complications [3]. These conditions are most commonly due to insulin resistance and excess androgen production, or hyperandrogenism.

Effects of Psychological Stress on Insulin Resistance

Psychological stress is a significant risk factor for insulin resistance, and therefore Type II diabetes. Understanding how stress plays a role in insulin resistance would be valuable in gaining more insight into diabetes and feasible preventative and therapeutic approaches. This review will examine the known mechanisms of insulin resistance, shed light on the factors contributing to it, and specifically discuss how psychological stress influences the risks associated with insulin resistance.