In the zombie-apocalypse video game and hit TV series The Last of Us, a fungus infects humans and takes control of their minds, mutating them into putrid monsters. This was was inspired by Ophiocordyceps, a genus of parasitic fungi that infects ants. Even though this fungus cannot affect humans, other parasites can. Studying the processes that underlie Ophiocordyceps infection can help us enhance our understanding of human parasites and other pathogens. This review will compile known factors and mechanisms involved in Ophiocordyceps’ manipulation of its host, from initial infection to death.