Over the past two decades, the psychedelic ketamine has gained traction among scientists and mental health providers as a potential alternative treatment for depression. However, ketamine’s actions on a molecular level are still not fully understood, and its adverse side effects present a recurrent challenge. This review will provide an overview of results from preclinical and clinical trials of ketamine-based therapeutics for major depression

Depression is typically treated with psychotherapy and/or medication, but research has also pointed to the efficacy of exercise therapy in supplementing psychotherapy. One novel exercise therapy is therapeutic climbing, in which a group of participants engages in both rock climbing and non-climbing activities such as a reflection or mindfulness activity under therapist guidance. This review will explore the current state of research on therapeutic climbing.