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The Effects of Exergaming on Cognitive Decline in Older Adults: A Systematic Review

With the increasing risk of Alzheimer’s disease and other neurodegenerative diseases in older adults in the U.S., alternative methods of preventing further cognitive decline have become a topic of interest. Exergaming, a form of exercise that combines physical exercise with mental stimulation, has been shown to improve the cognitive function of older adults. However, the methods of analyzing the specific cognitive benefits of exergames and their further implications have been widely varied. This review examines the different methods used in research studies that analyze the effects of exergaming on cognitive function in older adults and discusses future implications in preventing cognitive decline.

Modeling Alzheimer’s Disease Using Human Brain Organoids

Alzheimer’s Disease (AD) is a progressive neurodegenerative disease that starts with mild memory loss and progresses to the loss of the ability to carry out daily activities, ultimately leading to death. Recent advances in stem cell research have led to the development of in vitro self-assembling 3-dimensional models of the human brain, called human brain organoids, which can model pathological processes of AD assess the effectiveness of various drug treatments. This literature review will synthesize the research done on the use of 3D human brain organoids to model AD pathology and its use in developing and assessing treatments for AD.

Clearing the Cellular Landfill: The Use of Chaperone-Mediated Autophagy to Treat Alzheimer’s Disease

“Imagine someone has taken your brain and it’s an old file cabinet and spread all the files over the floor, and you have to put things back together,” describes Greg O’Brian, an award-winning political writer who was diagnosed with Alzheimer’s Disease in 2010. The disorienting feeling described by O’Brian in an interview with Medical Daily is familiar for those diagnosed with Alzheimer’s disease ...

Factors Involved in the Development of Alzheimer’s Disease

Alzheimer’s Disease (AD) is a terminal neurodegenerative disorder characterized by cognitive decline. As the most common cause of dementia, AD affects over 24 million people worldwide, and this number is only expected to increase due to greater life expectancies. Although this disease affects a great number of people, there is currently much that remains unknown about it ...

New Target For Alzheimer’s Treatment

A group of researchers studying brain cells have found a new potential target for pharmacological therapies that may help treat Alzheimer’s disease. Beta amyloid plaque, which appears to be a toxic build up of fragments of amyloid precursor protein (APP) in the brain, has long been associated with Alzheimer’s disease, and has been one of the major targets for Alzheimer’s treatment ...