Malaria’s long evolutionary history among humans and its mosquito vector has resulted in intense selection pressure on each organism to evolve traits that confer survival. This coevolution makes malaria a challenging disease to eradicate; therefore, achieving malarial control requires an extensive understanding of malaria’s evolutionary and life history. Malaria’s life and evolutionary history reveal that arresting mosquito longevity is the key to malarial control. This paper will demonstrate that an effective intervention strategy must take a multifaceted and ecologically conscious approach towards targeting the mosquito vector.