While the current leading forms of treatment for Crohn’s Disease have been immunosuppressive and biologic medications, more focus needs to be placed on alternative therapies for those who cannot tolerate the drugs that are frequently prescribed. One alternative therapy that is being researched is the implementation of a solely diet-based approach for the purpose of limiting disease activity. This review will evaluate the efficacy of the three main diet-based interventions as monotherapy—Exclusive Enteral Nutrition (EEN), Partial Enteral Nutrition (PEN), and the Crohn’s Disease Exclusion Diet (CDED)—with focus placed on the assessment of inflammatory markers and patient reported outcomes.