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Supplementing Immunostaining with Complementary Methods for a Holistic Understanding of the Mechanisms Behind COVID-19-Induced Anosmia

Introduction 

The exact mechanisms behind COVID-19-induced anosmia, or the complete loss of smell, remain unclear due to conflicting findings that fail to establish a direct and consistent link between viral presence, cellular damage, and the subsequent disruption of olfactory function and inflammation within the olfactory system. Anosmia affects nearly 19% of COVID-19 patients, lasting an average of two months after recovery, significantly reducing their quality of life [1].