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Chronological Shifts: How Circadian Rhythm Changes with Age in Mammals

Circadian rhythms in mammals are orchestrated by a highly prevalent timing system, at the heart of which lies a complex molecular process regulated by a central clock in the brain. Similar to other physiological systems, the circadian system undergoes degradation with age. This article aims to introduce the definition of circadian rhythm, delve into its fundamental principles, and explore the correlation between changes in circadian rhythm and the aging process.

The Quiet Truth of Circadian Rhythm: Light and Phosphorylation

Jay is a college student at UC Davis studying Biology, but like most college students, he lacks a consistent sleep schedule due to his late-night bouts of studying on his computer. There are many factors that impact his sleep, such as caffeine intake, room temperature, noisy roommates... and the list continues. But surprisingly, light generates the largest impact on our sleep. And from light, phosphorylation occurs, driving cell signaling within the body. Light drives circadian rhythm as it causes phosphate groups to activate many of the necessary proteins within the sleep mechanism.