Complex regional pain syndrome (CRPS), a neuroinflammatory disease, ranks number one on the McGill Pain Scale, topping fibromyalgia, cancer, and amputation without anesthetics. The development of CRPS typically occurs after trauma to the arm or leg (e.g., breaking of a bone, dislocation of a joint, surgical trauma to a limb) that results in a disproportionately high sensation of pain. This painful response is chronic and characterized by constant pain with additional flare-ups that last different amounts of time from person to person.