By Rachel Hull, Biochemistry and Molecular Biology, ’19 Author’s note I originally wrote this paper for my Biological Systems class, the instructor of which was interested in researching the physiological role of monocarboxylate transporter 1 (MCT1). He instructed his students to write an essay exploring this role in any way they wanted, and I chose to focus on the link between MCT1 and cancer. I enjoyed sifting through multiple strands of evidence for the reasons behind this link — strands that oftentimes were not in agreement with one another.
By: Anna Kirillova, Cell Biology, ‘19 Author’s Note: “This article was brought to my attention in my Human Genetics class (MCB 162) when we were discussing novel methodologies for diagnosis of fetal trisomies (Down Syndrome). The purpose of this review is to highlight how basic biology can translate into significant advancements in disease diagnosis. I hope that the reader will be intrigued by the new genetic technologies and will proceed onto reading the original research article using this review as a guide.”
By Briga Mullin, Biochemistry and Molecular Biology, ’15 The human body’s immune system has been developed to successfully battle foreign invaders including bacteria, parasites, and viruses. Immunotherapy is the idea that the power of the immune system can be utilized against diseases such as cancer. Typically, the immune system does not harm the body’s own cells, preventing it from being extremely effective against cancer. However with different medical interventions to strengthen the body’s immune response, it is possible to get an effective treatment (Cancer Immunotherapy 2015). A unique and exciting branch of immunotherapy involves oncolytic viruses, genetically modified viruses that are used to infect tumor cells and fight cancer (Vile, Ando, and Kirn 2002). One example of an oncolytic virus […]
Exciting, new gene therapy treatments for breast cancer are on the verge of making a breakthrough. With proper funding, these procedures could reduce the need for the surgical removal of organs. By Rayan Kaakati, Neurobiology, Physiology, and Behavior Being born female automatically enters one in a game of Russian roulette: About 1 in 8 women will develop invasive breast cancer over the course of their lifetime; for American women, breast cancer is the second leading cause of death (U.S. Breast Cancer Statistics). Breast cancer is a disease that starts in the tissues of the breast and is statistically fatal for one in thirty-two women (Breast Cancer Facts). Many women, throughout recorded history, have succumbed to this malignant disease. Rapid advancements […]
By Briga Mullin, Biochemistry and Molecular Biology, ’15 What do a smoker, a two week old embryo, a child with a broken wrist, and a metastatic tumor all have in common? While these are a diverse group of conditions, they all have cells that are experiencing the same process known as epithelial-mesenchymal transition (EMT). Mesenchymal cells are non-polarized, mobile, invasive, and their main function is to secrete extracellular matrix. In contrast, epithelial cells form our skin and the linings of our internal organs. They are normally polarized which means they have a directional structure and are uniformly oriented and are attached to a membrane to form a layer of epithelial tissue. Under certain conditions an EMT will occur and epithelial […]